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It is usually used when other common drugs like Clindamycin, minocycline, or benzoyl peroxide have failed to handle the acne. It is a vitamin A derivative and should not be used with vitamin A supplements. This is to prevent excessive build-up of vitamin A in your tissues vitamin A toxicity. Isotretinoin works by reducing sebum production, a type of facial oil produced by sweat sebaceous glands on the face. An excessive amount of sebum can lead to severe acne and if not properly treated, permanent tissue facial scaring can occur.

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